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Lysergic acid diethylamide LSD What is LSD? Lysergic acid diethylamide LSD first synthesized in 1938, is an extremely potent hallucinogen. It is synthetically made from lysergic acid, which is found in ergot, a fungus that grows on rye and other grains. It is so potent its doses tend to be in the microgram (mcg) range. …